Direct Relief's Replenishment Program has substantial benefits for patients and safety net partners. By enrolling into the program, clinics gain access to manufacturers’ brand medications at no cost. Unlike individual PAPs, medications accessed through the Replenishment Program are available to qualified patients at the time of care without any delay, resulting in improved patient care. Clinic staff is relieved of the burdens associated with individual PAPs, and through this program can screen patients and authorize the dispensing of program medications at the time of the visit. The initial pre-load and continuous replacement of medications results in substantial savings in both staff time and financial resources, thus allowing for pharmacy resources to be reallocated towards other clinic functions.